Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

Thermolabile 5,10-MethylenetetrahydrofoIate Reductase as a Cause of Mild Hyperhomocysteinemia

Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.

Mild hyperhomocysteinemia is a risk factor for atherosclerotic vascular disease. Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations. The purpose of th...

Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state.

The role of hyperhomocysteinemia (HHcy) as a cardiovascular risk factor remains a matter of debate, while it correlates with folates, it demonstrates inverse correlation with plasma homocysteine (Hcy) levels and vitamin B12 levels and reduces plasma Hcy levels following supplementation with multivitamins. The purpose of this study was to demonstrate that administering multivitamins at specific ...

Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM.

Hyperhomocysteinemia has been identified as an independent risk factor for arteriosclerotic diseases such as myocardial infarction (MI), peripheral arterial occlusive disease, and cerebrovascular disease (1^1). In contrast to the very low prevalence of homocysteinuria (a hereditary disease characterized by severe hyperhomocysteinemia, homocystinuria, and earlyonset atherosclerotic diseases), in...

and motor function . preserves

Oxidative damage has been suggested as a potential mechanism for both atherosclerosis and neurodegenerative disorders such as Parkinson's disease.' One report has noted a 2-5-fold increased risk of cardiovascular disease among patients with Parkinson's disease,2 suggesting that a common genetic variant may contribute to both diseases. One such candidate genetic factor, the ApoE-E4 allele, is fo...